Lipidomic profiling identifies signatures of metabolic risk
نویسندگان
چکیده
منابع مشابه
Metabolite profiling identifies pathways associated with metabolic risk in humans.
BACKGROUND Although metabolic risk factors are known to cluster in individuals who are prone to developing diabetes mellitus and cardiovascular disease, the underlying biological mechanisms remain poorly understood. METHODS AND RESULTS To identify pathways associated with cardiometabolic risk, we used liquid chromatography/mass spectrometry to determine the plasma concentrations of 45 distinc...
متن کاملLipidomic Profiling of Influenza Infection Identifies Mediators that Induce and Resolve Inflammation
Bioactive lipid mediators play a crucial role in the induction and resolution of inflammation. To elucidate their involvement during influenza infection, liquid chromatography/mass spectrometry lipidomic profiling of 141 lipid species was performed on a mouse influenza model using two viruses of significantly different pathogenicity. Infection by the low-pathogenicity strain X31/H3N2 induced a ...
متن کاملTranscriptional profiling identifies the metabolic phenotype of gonococcal biofilms.
Neisseria gonorrhoeae, the etiologic agent of gonorrhea, is frequently asymptomatic in women, often leading to chronic infections. One factor contributing to this may be biofilm formation. N. gonorrhoeae can form biofilms on glass and plastic surfaces. There is also evidence that biofilm formation may occur during natural cervical infection. To further study the mechanism of gonococcal biofilm ...
متن کاملComparative metabolic and lipidomic profiling of human breast cancer cells with different metastatic potentials
This study conducted comprehensive and comparative metabolic and lipidomic profiling of a human epithelial breast cell line (MCF-10A), a slightly metastatic (MCF-7), and a highly metastatic (MDA-MB-231) breast cancer cell line using gas chromatography mass spectrometry (GC-MS) and direct infusion mass spectrometry (DI-MS). Among 39 metabolites identified by GC-MS analysis, xanthine, glucose-6-p...
متن کاملNAFLD Metabolic Signatures by HR-MAS Molecular Profiling
The liver performs a large number of metabolic functions including the use of fatty acids for energy production and interconversion of biosynthetic precursors. As a consequence, the liver plays a critical role in fat storage and retrieval. Liver pathophysiology can range from steatosis and steatohepatitis to fibrosis, cirrhosis and even liver cancer. Among these pathologies, non-alcoholic fatty...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: EBioMedicine
سال: 2020
ISSN: 2352-3964
DOI: 10.1016/j.ebiom.2019.10.046